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Disturbances of the Stress Response: The Role of the Hypothalamic-Pituitary-Adrenal Axis During Alcohol Withdrawal and Abstinence-

  • Title: Disturbances of the Stress Response: The Role of the Hypothalamic-Pituitary-Adrenal Axis During Alcohol Withdrawal and Abstinence
  • Author:
  • Released: 0000-00-00
  • Language:
  • Pages: 12
  • ISBN:
  • ISBN13:
  • ASIN: B008IVOBHQ

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Interactions among the brain, the pituitary gland, and the adrenal glands (i.e., the
hypothalamic-pituitary-adrenal [HPA] axis) help regulate the body’s response to stress. The
adrenal hormone cortisol plays a key role in stress reduction through its effects on multiple
body systems. Excessive cortisol activity during both chronic alcohol administration and
withdrawal may underlie some of the clinical complications of alcoholism, including
increased risk of infectious diseases; bone, muscle, and reproductive system changes; altered
energy metabolism; and disorders of mood and intellect. Despite excessive cortisol levels
during intoxication and withdrawal, however, the HPA axis becomes less responsive to stress
during abstinence, potentially resulting in an impaired capacity to cope with relapse-inducing
stressors. pdf
 
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